Prognostic role of macrophages and mast cells in the microenvironment of hepatocellular carcinoma after resection

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F24%3A10474861" target="_blank" >RIV/00216208:11140/24:10474861 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11120/24:43926593 RIV/00669806:_____/24:10474861

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tOATs_gef-" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tOATs_gef-</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12885-024-11904-8" target="_blank" >10.1186/s12885-024-11904-8</a>

Result language

angličtina

Original language name

Prognostic role of macrophages and mast cells in the microenvironment of hepatocellular carcinoma after resection

Original language description

BACKGROUND: The prognostic significance of mast cells and different phenotypes of macrophages in the microenvironment of hepatocellular carcinoma (HCC) following resection is unclear. We aimed in this study to assess the local distribution of infiltrating macrophages and mast cells of specific phenotypes in tissues of HCC and to evaluate their prognostic values for survival of post-surgical patients. METHODS: The clinicopathological and follow-up data of 70 patients with HCC, who underwent curative resection of tumor from 1997 to 2019, were collected. The infiltration of CD68+ and CD163+ macrophages and CD117+ mast cells was assessed immunohistochemically in representative resected specimens of HCC and adjacent tissues. The area fraction (AF) of positively stained cells was estimated automatically using QuPath image analysis software in several regions, such as tumor center (TC), inner margin (IM), outer margin (OM), and peritumor (PT) area. The prognostic significance of immune cells, individually and in associations, for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS) was evaluated using Kaplan-Meier and Cox regression analyses. RESULTS: High AF of CD68+ macrophages in TC and IM and high AF of mast cells in IM and PT area were associated with a longer DFS. High AF of CD163+ macrophages in PT area correlated with a shorter DFS. Patients from CD163TC(high) &amp; CD68TC(low) group had a shorter DFS compared to all the rest of the groups, and cases with CD163IM(low) &amp; CD68IM(high) demonstrated significantly longer DFS compared to low AF of both markers. Patients from CD68IM(high) &amp; CD163PT(low) group, CD117IM(high) &amp; CD163PT(low) group, and CD117PT(high) &amp; CD163PT(low) group had a significantly longer DFS compared to all other combinations of respective cells. CONCLUSIONS: The individual prognostic impact of CD68+ and CD163+ macrophages and mast cells in the microenvironment of HCC after resection depends on their abundance and location, whereas the cumulative impact is built upon combination of different cell phenotypes within and between regions.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/NU21-03-00506" target="_blank" >NU21-03-00506: TUMOR CELL AND MUTATIONAL LANDSCAPE IN COLORECTAL CANCER DEVELOPMENT</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BMC Cancer

ISSN

1471-2407

e-ISSN

1471-2407

Volume of the periodical

24

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

142

UT code for WoS article

001153842400004

EID of the result in the Scopus database

2-s2.0-85183667312