Undifferentiated round cell sarcomas of the skin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F25%3A10489095" target="_blank" >RIV/00216208:11140/25:10489095 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9FR0ESbEoU" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=9FR0ESbEoU</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mpdhp.2024.11.001" target="_blank" >10.1016/j.mpdhp.2024.11.001</a>
Alternative languages
Result language
angličtina
Original language name
Undifferentiated round cell sarcomas of the skin
Original language description
Undifferentiated round cell sarcomas are a heterogenous group of bone/soft tissue neoplasms characterized by relatively monotonous small blue round cell morphology, with high nuclear/cytoplasmic ratio and unspecific or overlapping immunohistochemical findings. According to the WHO Classification of Tumors of Soft tissue and Bone, this group includes Ewing sarcoma, CIC-rearranged sarcoma, sarcoma with BCOR genetic alterations, and round cell sarcoma with EWSR1::non-ETS fusions. Although they are quite rare in cutaneous/subcutaneous localization, they should always be included in the differential diagnosis of poorly differentiated round cell cutaneous tumors. Among them, subcutaneous/cutaneous Ewing sarcoma and superficial CIC- rearranged sarcoma are the most common entities and distinction between them is extremely important, as Ewing sarcoma has a significantly better prognosis, particularly in the superficial location, as opposed to CIC-rearranged sarcoma which is a highly aggressive sarcoma with a poor clinical outcome. Molecular analysis is required for diagnostic confirmation, and it includes FISH, standard sequencing-based methods and recently also DNA methylation profiling. This article provides a summary on contemporary knowledge regarding undifferentiated cutaneous round cell sarcomas, with an emphasis on characteristic histologic and immunohistochemical features as well as diagnostic pitfalls, including differential diagnosis and potential false-negative results in molecular assays.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diagnostic Histopathology
ISSN
1756-2317
e-ISSN
1876-7621
Volume of the periodical
31
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
45-54
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85212324094