Elevated Risk of HPV-Associated Oropharyngeal Cancers in Husbands of Women With Anogenital Cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F25%3A10501609" target="_blank" >RIV/00216208:11140/25:10501609 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=BYjZ0UZY9U" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=BYjZ0UZY9U</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cnr2.70333" target="_blank" >10.1002/cnr2.70333</a>
Alternative languages
Result language
angličtina
Original language name
Elevated Risk of HPV-Associated Oropharyngeal Cancers in Husbands of Women With Anogenital Cancer
Original language description
Introduction: Human papillomavirus (HPV) infection is associated with tonsillar and base-of-tongue squamous cell carcinomas (TSCC/BOTSCC). We evaluated the relative risk (RR) of TSCC/BOTSCC in the husbands of women with anogenital cancer using the Swedish family database. Methods: The Swedish family database includes 3.5 million families and 16 million individuals identified since 1932 and linked to cancer data from 1958 to 2015. We explored the RR of TSCC/BOTSCC in husbands of women diagnosed with anogenital (anal, vulvar/vaginal, cervical) cancer or cervical carcinoma in situ (CIS) as compared to husbands of controls. Results: The RR of TSCC/BOTSCC in husbands of women with invasive anogenital cancer increased by calendar time and decreasing ages at diagnoses. In 2002-2015, the RR peaked at 5.35 (95% CI 2.21-13.0) in TSCC/BOTSCC cases diagnosed at age < 50 years. In husbands of women with CIS, the RR for TSCC/BOTSCC was 2-fold irrespective of time period. Conclusions: Clustering of increased HPV-associated invasive cancer risk in spouses appears to be calendar-time dependent. This introduces a new perspective in cancer science: an increase of familial HPV-associated cancer risk in spouses.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Reports
ISSN
2573-8348
e-ISSN
2573-8348
Volume of the periodical
8
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
e70333
UT code for WoS article
001561074500001
EID of the result in the Scopus database
2-s2.0-105014622347