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Expression of Leu-7 in myocardial sleeves around human pulmonary veins

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F03%3A00004228" target="_blank" >RIV/00216208:11150/03:00004228 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023001:_____/03:00000935

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Expression of Leu-7 in myocardial sleeves around human pulmonary veins

  • Original language description

    Background: Atrial fibrillation (AF) is the most common sustained clinical arrhythmia. Myocardial sleeves onto pulmonary veins (PVs) have been recognized as a frequent site of origin of focal triggers for this arrhythmia. Expression of Leu-7 has been hypothesized to correspond with abnormal atrial automaticity. Objective: To evaluate a possible role of the Leu-7 immunoreactivity in AF patients, we studied Leu-7 expression in myocardial sleeves. Methods: Leu-7 was studied immunohistochemically in paraffin-embedded specimens from 55 human autopsied hearts (mean age 69 years, range 42-94 years, 34 males, 21 females). Twenty-two of the subjects had previous history of AF. Conclusions: Leu-7 positivity, hypothesized to correspond with abnormal atrial automaticity, can be detected in some myocardial sleeves around PVs. However, no statistical relationship to previous history of AF was found.

  • Czech name

    Exprese Leu-7 v myokardiálních rukávcích okolo plicních žil člověka

  • Czech description

    Úvod: fibrilace síní (AF) je nejčastějším typem klinicky pozorované arytmie. Myokardiální rukávce na plicních žílách (PV) jsou častým místem původu fokálních iniciátorů této arytmie. Existuje hypotéza, že exprese Leu-7 koresponduje s abnormální automaticitou srdečních síní. Cíl: zhodnotit možnou úlohu imunoreaktivity Leu-7 u pacientů s AF v jejich myokardiálních rukávcích. Závěry: Určitá pozitivita na Leu-7 se dá nalézt u některých myokardiálních rukávců okolo PV. Na druhé straně však nebyl nalezen žádný vztah mezi touto aktivitou a předchozí historií AF.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FP - Other medical fields

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2003

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Cardiovascular Pathology

  • ISSN

    1054-8807

  • e-ISSN

  • Volume of the periodical

    12

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    4

  • Pages from-to

    263-266

  • UT code for WoS article

  • EID of the result in the Scopus database