Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F06%3A00004259" target="_blank" >RIV/00216208:11150/06:00004259 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/06:00006892
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Cardioprotective effects of a novel iron chelator, pyridoxal 2-chlorobenzoyl hydrazone, in the rabbit model of daunorubicin-induced cardiotoxicity
Original language description
In this study the cardioprotective effects of the novel lipophilic iron chelator against chronic anthracycline cardiotoxicity were investigated. Using 10 mg/kg of the chelator administered 30 min before the every daunorubicin dose the significant cardioprotection was obtained (as shown by prevention of cardiac-related deaths, improved functional, biochemical and morphological parameters). On the other hand escalation of the dose to the 25 mg/kg did not improved cardiovascular parameters, on the contrary, the cardioprotective potential was lost and early extracardiac toxicity was observed.
Czech name
Kardioprotektivní účinky nového chelátoru železa, pyridoxal 2-chlorbenzoyl hydrazonu, na modelu daunorubicinem-indukované kardiotoxicity u králíka
Czech description
V této studii byly sledovány kardioprotektivní účinky nového chelátoru železa vůči antracycklinové kardiotoxicitě. Chelátor podaný v dávce 10 mg/kg 30 min před daunorubicinem navodil signifikantní kardioprotekci (jak je patrno z prevence kardiální mortality, zlepšení funkčních biochemických a morfologických parametrů). Na druhou stranu, zvýšení dávky na 25 mg/kg nevedlo ke zlepšení kardiovaskulárních parametrů, naopak, kardioprotektivní potenciál vymizel a byla pozorována časná extrakardiální toxicita.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GP305%2F05%2FP156" target="_blank" >GP305/05/P156: Study of protective effects of novel iron chelators in the heart injury induced by oxidative stress and anthracycline cytostatics</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2006
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmacology and Experimental Therapeutics
ISSN
0022-3565
e-ISSN
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Volume of the periodical
319
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
1336-1347
UT code for WoS article
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EID of the result in the Scopus database
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