DNA Damage Signaling in Human Skin Cells Exposed to Hexavalent Chromium

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F09%3A00208684" target="_blank" >RIV/00216208:11150/09:00208684 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/09:00201687
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
DNA Damage Signaling in Human Skin Cells Exposed to Hexavalent Chromium
Original language description
The purpose of this study was to investigate the initial stages of Cr (VI)-induced DNA damaging in normal human skin fibroblasts. Primary human skin fibroblasts were exposed to Cr (VI) at a concentration range of 1-50 ?M during 24 h. Our results confirmthat Cr (VI) dose-dependently stimulates both directly (via its reactive metabolic intermediates) and indirectly (through generated oxidative stress) DNA damaging which results in the activation of DNA damage response pathway during 24 h of treatment. The important members of this pathway include ATM/ATR kinases which stimulate their downstream targets Chk1, Chk2 and p53 in mediating transient G2/M cell cycle arrest and activating cell death characterized by the specific cleavage of PARP. Inhibition ofATM/ATR pathway and suppresion of oxidative stress in exposed cells significantly suppressed cell damage characterized by specific PARP cleavage.
Czech name
—
Czech description
—

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)