Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F09%3A00208761" target="_blank" >RIV/00216208:11150/09:00208761 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/09:00201746

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells

Original language description

Cytotoxicity and apoptosis induced by etoposide were studied during 72 hr in human melanoma cells. Etoposide initiated DNA-damage signaling via ATM kinase and activated p53 pathway and caspase-2. In response to treatment with etoposide, mitochondria of melanoma cells first increased their abundance and activity, and at later treatment intervals their dynamic behaviour and functions became suppressed. Observed mitochondrial perturbation was not preceded by membrane potential loss but cytochrome C releasewas observed together with a rise in caspase-9 and caspase-3 activities. The pharmacological inhibition of relevant induced targets proved the importance of ATM and caspase-2 in etoposide-mediated cytotoxicity and apoptosis.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Investigation

ISSN

0735-7907

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

7

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

—

UT code for WoS article

000268391300002

EID of the result in the Scopus database

—