Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10062300" target="_blank" >RIV/00216208:11150/10:10062300 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/10:10062300

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features

Original language description

Elevated expression of angiopoietin-2 (Ang-2), was recently reported in CLL. We quantitated Ang-2 mRNA in purified mononuclear cells of 33 untreated CLL patients and compared the transcript levels to traditional as well as modern prognostic factors in patients with CLL. Elevated Ang-2 mRNA concentrations were detected in 12 cases; 21 patients had very low or undetectable levels of Ang-2 transcript. There was significant association between high Ang-2 mRNA levels and unmutated IgVH genes (n=27, P=0.010)and with CD38 expression (n=32, P=0.011), but not with ZAP-70 expression (n=32,P=0.784), Rai stage (n=33, P=0.305) or stable versus progressive clinical course (n=33,P=0.443). There was a trend towards shorter progression-free survival in patients with high Ang-2 expression; however, it did not reach statistical significance (P=0.090). Our pilot data show that Ang-2 mRNA is differentially expressed in patients with CLL and its increased expression appears to be associated with poor progn

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Hematology

ISSN

1024-5332

e-ISSN

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Volume of the periodical

15

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

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UT code for WoS article

000280648600004

EID of the result in the Scopus database

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