Expression profiles in viral responsive genes in oral and oropharyngeal cancers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10070590" target="_blank" >RIV/00216208:11150/10:10070590 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Expression profiles in viral responsive genes in oral and oropharyngeal cancers

Original language description

The association between Human Papillomavirus (HPV) DNA and oropharyngeal squamous cell carcinoma (SCC) has been supported by numerous studies strongly implicating HPV infection as a factor in the development of this cancer. In contrast, squamous cell carcinoma of the oral cavity has not been associated with HPV DNA, suggesting alternate aetiologic factors. Quantitative polymerace chain reaction (qPCR) studies to compare the expression levels of genes that may act as indicators of persistent stimulationby viral antigen in both oral cavity and oropharyngeal squamous cell cancers was done. Results demonstrate that HPV-positive oropharyngeal tumours displayed gene expression patterns indicative of a viral signature and that HPVnegative oropharyngeal tumours do not display similar expression patterns. No evidence of either a viral or bacterial signature in the oral tumours was found.10.1016/j.ejca.2010.01.026

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Cancer

ISSN

0959-8049

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

6

Pages from-to

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UT code for WoS article

000277812400026

EID of the result in the Scopus database

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