Effect of S-adenosylmethionine on liver regeneration induced by partial hepatectomy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10078877" target="_blank" >RIV/00216208:11150/10:10078877 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25520/10:39882916
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effect of S-adenosylmethionine on liver regeneration induced by partial hepatectomy
Original language description
S-adenosylmethionine (SAMe) is a key metabolite regulating growth, differentiation and death of hepatocytes. Experimentally, exogenous SAMe has been documented to attenuate hepatocarcinogenesis. The aim of our study was to evaluate the effect of SAMe onproliferation of hepatocytes that are not cancerously transformed. The results have documented the inhibition of the liver regeneration by SAMe that may be mediated by the suppression of liver fat accumulation. Cell GSH level correlating with the growthrate was not affected by SAMe. Prevention from the decrease in the intracellular content of SAMe, as a factor attenuating regeneration remains to be verified.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Project
<a href="/en/project/NS9739" target="_blank" >NS9739: Can Statins Attenuate a development of cholestatic liver disease?</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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