Radiosensitivity of CD3-CD8+CD56+ NK cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F10%3A10081136" target="_blank" >RIV/00216208:11150/10:10081136 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/10:00002378 RIV/00179906:_____/10:10081136
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Radiosensitivity of CD3-CD8+CD56+ NK cells
Original language description
The effect of lower doses (0.5-3.0 Gy) of gamma radiation on radiosensitivity of CD3-/CD8+ NK cells subpopulation isolated from the peripheral blood of healthy volunteers was studied 48 h after the irradiation. Only a subtle increase in terms of induction of apoptosis (A+cells), was observed in Annexin positive CD3-/CD8+ NK cells. The assessment of the relative presence of CD3-/CD8+ NK cells in Annexin negative populations of lymphocytes considerably contributes to the elimination of individual variability and could be useful in biodosimetry. Living CD3-/CD8+; Annexin negative NK cells were analyzed using five-color flow cytometry 16 hours after irradiation by the doses of 1-10 Gy. The study was carried out on NK cells subsets CD3-/CD8 - CD16+, CD56(dim) and CD56(bright). NK cells characterized with their low-density expression of CD56(dim) are more cytotoxic and express CD16.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OVUOFVZ200806" target="_blank" >OVUOFVZ200806: Noninvasive measurement of proinflamatory markers of oxidative stress in irradiated as an indicator of received dose of radiation. Protective role of acetyl-L-carnitine</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Radiation Measurements
ISSN
1350-4487
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
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UT code for WoS article
000283466200006
EID of the result in the Scopus database
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