Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10104474" target="_blank" >RIV/00216208:11150/11:10104474 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/11:00002424 RIV/00179906:_____/11:10104474
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1386653210003987" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1386653210003987</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jcv.2010.09.014" target="_blank" >10.1016/j.jcv.2010.09.014</a>

Result language
angličtina
Original language name
Fulminant hepatitis and death associated with disseminated varicella in an immunocompromised adult from the Czech Republic caused by a wild-type clade 4 varicella-zoster virus strain
Original language description
Varicella zoster virus typically causes a benign disease in childhood called varicella (chickenpox) and can reactivate in adults as a dermatomally distributed,painful rash illness known as herpes zoster (HZ). Infection with VZV can however lead to severecomplications in immunocompromised patients that can result in hospitalization and, occasionally, death. Here we describe a patient, who acquired primary VZV infection during a 3-week-long treatment regimen with corticosteroids. The disease took a fulminant course, leading to a liver failure and severe coagulopathy. The patient died 9 days following hospital admission, despite intensive antiviral and supportive treatment. Wild-type VZV DNA was detected from multiple samples from esophagus, liver and skin. Genotypic analysis based on single nucleotide polymorphism profiles in open reading frames (ORFs) 21,22 and 50 identified this strain as a clade 4 isolate, which is typically found in tropical countries. This is the first description
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FN - Epidemiology, infection diseases and clinical immunology
OECD FORD branch
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Project
<a href="/en/project/GAP304%2F10%2F1161" target="_blank" >GAP304/10/1161: Role of virus-associated host-derived proteins in virus induced T cell dysfunction</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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