Accumulation of DNA Damage and Cell Death after Fractionated Irradiation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10104927" target="_blank" >RIV/00216208:11150/11:10104927 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/11:00367046 RIV/60162694:G44__/11:00002528

Result on the web

<a href="http://www.rrjournal.org/doi/pdf/10.1667/RR2478.1" target="_blank" >http://www.rrjournal.org/doi/pdf/10.1667/RR2478.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1667/RR2478.1" target="_blank" >10.1667/RR2478.1</a>

Result language

angličtina

Original language name

Accumulation of DNA Damage and Cell Death after Fractionated Irradiation

Original language description

The purpose of this work was to determine how fractionated radiation used in the treatment of tumors affects the ability of cancer as well as normal cells to repair induced DNA double-strand breaks (DSBs) and how cells that have lost this ability die. Lymphocytic leukemia cells (MOLT4) were used as an experimental model, and the results were compared to those for normal cell types. The results show that cancer and normal cells were mostly unable to repair all DSBs before the next radiation dose inducednew DNA damage. Accumulation of DSBs was observed in normal human fibroblasts and healthy lymphocytes irradiated in vitro after the second radiation dose. The lymphocytic leukemia cells irradiated with 4 X 1 Gy and a single dose of 4 Gy had very similarsurvival; however, there was a big difference between human fibroblasts irradiated with 4 X 1.5 Gy and a single dose of 6 Gy. These results suggest that exponentially growing lymphocytic leukemia cells, similar to rapidly proliferating tu

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Radiation Research

ISSN

0033-7587

e-ISSN

—

Volume of the periodical

175

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

708-718

UT code for WoS article

000291336500004

EID of the result in the Scopus database

—