The Importance of Senescence in Ionizing Radiation-Induced Tumour Suppression

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10104943" target="_blank" >RIV/00216208:11150/11:10104943 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/11:00002535
Result on the web
<a href="http://search.proquest.com/docview/868180330/fulltextPDF?accountid=15618" target="_blank" >http://search.proquest.com/docview/868180330/fulltextPDF?accountid=15618</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The Importance of Senescence in Ionizing Radiation-Induced Tumour Suppression
Original language description
Cellular senescence is a condition of long-lasting proliferation arrest, induced in cells in response to various stressors. These stressors include telomere shortening and/or dysfunction, DNA damage, and oncogene signalling. Epithelial and mesenchymal cells and also tumour cells derived from these tissues are more resistant to radiation-induced apoptosis and respond to irradiation mainly by senescence. Senescence-associated molecular mechanisms related to the activation of canonical DNA damage pathway ATM-p53 as well as mechanisms related to the extracellular signals, cytokine increase and up-regulation of their receptors are discussed in this review.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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