A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) andsatraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10106142" target="_blank" >RIV/00216208:11150/11:10106142 - isvavai.cz</a>
Result on the web
<a href="http://www.springerlink.com/content/p1083l5308018434/fulltext.pdf" target="_blank" >http://www.springerlink.com/content/p1083l5308018434/fulltext.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00280-010-1411-0" target="_blank" >10.1007/s00280-010-1411-0</a>
Alternative languages
Result language
angličtina
Original language name
A comparative study of pharmacokinetics, urinary excretion and tissue distribution of platinum in rats following a single-dose oral administration of two platinum(IV) complexes LA-12 (OC-6-43)-bis(acetato)(1-adamantylamine)amminedichloro platinum(IV) andsatraplatin (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum(IV)
Original language description
The study compared the pharmacokinetics, tissue distribution, and urinary excretion of platinum in rats after single oral doses of LA-12 and satraplatin. Characteristics of platinum exposure evaluated in the plasma, plasma ultrafiltrate and kidney and liver tissues. In the dose range of 37.5-300mg/kg, platinum concentrations increased less than in the proportion to the dose and, the fraction of dose exctreted in urine decreased. For both drugs, a dose-related decrease in the extent of oral bioavailability was observed most likely due to saturable intestinal absorption.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Chemotherapy and Pharmacology
ISSN
0344-5704
e-ISSN
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Volume of the periodical
67
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
1247-1256
UT code for WoS article
000291036500004
EID of the result in the Scopus database
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