The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F11%3A10108580" target="_blank" >RIV/00216208:11150/11:10108580 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/11:10108580

Result on the web

<a href="http://86.120.250.122:8082/2011/numarul1/fulltext/The%20Effect%20of%20Oral%20Sodium%20Loading%20and%20Saline%20Infusion%20on%20Direct%20Active%20Renin%20in%20Healthy%20Volunteers.pdf" target="_blank" >http://86.120.250.122:8082/2011/numarul1/fulltext/The%20Effect%20of%20Oral%20Sodium%20Loading%20and%20Saline%20Infusion%20on%20Direct%20Active%20Renin%20in%20Healthy%20Volunteers.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4183/aeb.2011.33" target="_blank" >10.4183/aeb.2011.33</a>

Result language

angličtina

Original language name

The effect of oral sodium loading and saline infusion on direct active renin in healthy volunteers

Original language description

In patients with suspected primary aldosteronism (PA), the aldosteroneto-renin ratio (ARR) is the most frequently recommended screening test. Further evaluation is based on hormonal changes during volume expansion. Both analyses are critically dependenton an accurate estimation of renin concentration. Direct active renin (DAR) is a novel laboratory technique used for plasma renin assessment. The objective of this study was to evaluate DAR for use in PA diagnostic work-ups. The study enrolled 69 healthyvolunteers. Blood sampling was conducted before and after an increase in oral salt intake. Furthermore, a subset of 32 individuals uderwent a saline infusion suppression terst. DAR and serum aldosterone were measured in all blood samples. To calculate the ARR, serum aldosterone and DAR were expressed in ng/L. ARR values (median (range); 97,5 percentile) associated with normal and elevated oral salt intake were 8.4 (0.6-37.7); 26.3, and 6.8 (1.1-37.7); 19.6, respectively. DAR and serum a

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Endocrinology

ISSN

1841-0987

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

1

Country of publishing house

RO - ROMANIA

Number of pages

6

Pages from-to

33-38

UT code for WoS article

000289007600004

EID of the result in the Scopus database

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