The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F12%3A10124769" target="_blank" >RIV/00216208:11150/12:10124769 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/12:10124769
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs13105-012-0150-6" target="_blank" >http://link.springer.com/article/10.1007%2Fs13105-012-0150-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13105-012-0150-6" target="_blank" >10.1007/s13105-012-0150-6</a>
Alternative languages
Result language
angličtina
Original language name
The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle
Original language description
The main purpose of this study was determining the effect of various doses of endotoxin on protein and amino acid metabolism in two types of rat skeletal muscle. Sepsis was induced by intraperitoneal administration of endotoxin in a dose of 1, 3 and 5 mg/kg body weithg (bw). After 24 h, extensor digitorum longus (EDL) and soleus (SOL) muscles were isolated and used for determination of total and myofibrillar proteolysis, protein synthesis, activity of cathepsins B and L, chymotrypsin-like activity of proteasome and amino acid release. The dose of 5 mg of endotoxin/kg bw induced the most significant changes in parameters of the protein and amino acid metabolism measured and could be therefore considered appropriate for studies of protein catabolism in young rat skeletal muscle at 24 h after endotoxin treatment.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Physiology and Biochemistry
ISSN
1138-7548
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
3
Country of publishing house
ES - SPAIN
Number of pages
11
Pages from-to
385-395
UT code for WoS article
000307513500009
EID of the result in the Scopus database
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