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The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F12%3A10124769" target="_blank" >RIV/00216208:11150/12:10124769 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11160/12:10124769

  • Result on the web

    <a href="http://link.springer.com/article/10.1007%2Fs13105-012-0150-6" target="_blank" >http://link.springer.com/article/10.1007%2Fs13105-012-0150-6</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s13105-012-0150-6" target="_blank" >10.1007/s13105-012-0150-6</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The dose-dependent effects of endotoxin on protein metabolism in two types of rat skeletal muscle

  • Original language description

    The main purpose of this study was determining the effect of various doses of endotoxin on protein and amino acid metabolism in two types of rat skeletal muscle. Sepsis was induced by intraperitoneal administration of endotoxin in a dose of 1, 3 and 5 mg/kg body weithg (bw). After 24 h, extensor digitorum longus (EDL) and soleus (SOL) muscles were isolated and used for determination of total and myofibrillar proteolysis, protein synthesis, activity of cathepsins B and L, chymotrypsin-like activity of proteasome and amino acid release. The dose of 5 mg of endotoxin/kg bw induced the most significant changes in parameters of the protein and amino acid metabolism measured and could be therefore considered appropriate for studies of protein catabolism in young rat skeletal muscle at 24 h after endotoxin treatment.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    ED - Physiology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Physiology and Biochemistry

  • ISSN

    1138-7548

  • e-ISSN

  • Volume of the periodical

    68

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    ES - SPAIN

  • Number of pages

    11

  • Pages from-to

    385-395

  • UT code for WoS article

    000307513500009

  • EID of the result in the Scopus database