A pilot study to monitor Graves' Ophthalmopathy with a combination of pattern-reversal and motion-onset visual evoked potentials

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F12%3A10125479" target="_blank" >RIV/00216208:11150/12:10125479 - isvavai.cz</a>
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1002/jca.21243/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jca.21243/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jca.21243" target="_blank" >10.1002/jca.21243</a>

Result language
angličtina
Original language name
A pilot study to monitor Graves' Ophthalmopathy with a combination of pattern-reversal and motion-onset visual evoked potentials
Original language description
Objective: The aim of this pilot study was to evaluate the efficacy of visual evoked potentials (VEPs) in the monitoring of visual function during a high-dose intravenous steroid pulse therapy and apheresis treatment of severe Graves' ophthalmopathy (GO). Patients and Research Design: Nine patients with severe and active GO were treated with high-dose Methylprednisolone (1 g/day 3 times within 1 week, then 0.5 g/day 7 times for 2 weeks) combined with plasma filtration (twice a week in weeks 1, 2, 4, 7,and 10). Pattern-reversal and motion-onset VEPs were examined three times, pre-treatment, after steroid pulses, and after the last apheresis. Results: After ten steroid pulses, the visual acuity was significantly better and the pattern-reversal VEP amplitudes (element size of only 20') had a similar trend for improvement. However, this effect disappeared after seven weeks when only apheresis treatment was performed. No significant changes in the latencies of any of the tested VEP variant
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Project
<a href="/en/project/GA309%2F09%2F0869" target="_blank" >GA309/09/0869: Pre-attentional processing of visual information in man: electrophysiological study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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