Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F13%3A10130773" target="_blank" >RIV/00216208:11150/13:10130773 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/13:10130773 RIV/60162694:G44__/13:43874979
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0143400412004638" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0143400412004638</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.placenta.2012.11.028" target="_blank" >10.1016/j.placenta.2012.11.028</a>

Result language
angličtina
Original language name
Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM
Original language description
Introduction: The presence of microbial invasion of the amniotic cavity (MIAC) and histological chorioamnionitis (HCA) is associated with adverse neonatal outcomes in pregnancies complicated by preterm prelabor rupture of membranes (pPROM). Therefore, there is an urgent need to identify new biomarkers revealing these conditions. The objective of this study is to identify possible biomarkers and their underlying biofunctions in pPROM pregnancies with and without MIAC and HCA. Methods: A total of 72 womenwith pPROM were recruited. Only women with both MIAC and HCA (n 1/4 19) and all women without these complications (n 1/4 19) having the same range of gestational ages at sampling were included in the study. Samples of amniotic fluid were obtained by transabdominal amniocentesis, processed and analyzed using quantitative shotgun proteomics. Ingenuity pathway analysis was used to identify molecular networks that involve altered proteins. Results: Network interaction identified by ingenuit
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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