Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F13%3A10173576" target="_blank" >RIV/00216208:11150/13:10173576 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Selenite-Mediated Cellular Stress, Apoptosis and Autophagy in Colon Cancer Cells
Original language description
Colorectal carcinoma (CRC) continues to be a major problem in developed countries, and successful preventive strategies concerning this malignancy are still missing. Sodium selenite has emerged as a potential chemopreventive agent due to a number of specials effects which produce colon cancer cells, regardless of their status. Selenite has been able to decrease cell proliferation and induce cytotoxicity by several mechanisms. These include direct inhibition of several molecular targets, signaling pathways (p53-dependent, mTOR, p38, JNK), or subcellular compartments (mitochondria), as well as activation of apoptosis and autophagy. Our data combined with results of studies conducted by other reserarch groups demonstrate a close connection between selenite-induced oxidative stress and apoptosis. In addition, the concurrent existence of autophagy and apoptosis in selenite-treated cells, their mutual relationship, and diverse regulatory patterns upon differing p53 status of cells suggest a
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Book/collection name
Autophagy: cancer, other pathologies, inflammation, immunity infection, and aging. Volume 1, Molecular Mechanisms
ISBN
978-0-12-405530-8
Number of pages of the result
13
Pages from-to
221-233
Number of pages of the book
329
Publisher name
Elsevier
Place of publication
Amsterdam
UT code for WoS chapter
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