Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10196731" target="_blank" >RIV/00216208:11150/14:10196731 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs10495-013-0959-7" target="_blank" >http://link.springer.com/article/10.1007%2Fs10495-013-0959-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10495-013-0959-7" target="_blank" >10.1007/s10495-013-0959-7</a>
Alternative languages
Result language
angličtina
Original language name
Sulforaphane-induced apoptosis involves p53 and p38 in melanoma cells
Original language description
In malignant melanoma complex reprogramming of cell death and survival pathways leads to increased chemoristance and poor longer-term survival. Sulforaphane (SF) is a promising isothiocyanate compound accurring in cruciferous plants with reported antiproliferative and proapoptotic activity in several tumor cell lines including melanoma. In this work we investigated the effects of SF in several melanoma cell lines and fresh melanoma cultivates. We found that SF is cytotoxic and induces mitochondrial, caspase-dependent apoptosis in our study model, however with lower efficiency in fresh melanoma cultivates. Moreover, our rsults indicate that in melanoma cell lines and fresh melanoma cultivates SF induces multiple signaling including oxidative stress-mediated activation of DNA-damage response pathway, changes in p38 kinase activity and enhanced expression of Bax and Puma proapoptotic proteins. In addition, in SF-exposed p53-mutant melanoma cells Puma expression seem to be under p38 contro
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Apoptosis : an international journal on programmed cell death
ISSN
1360-8185
e-ISSN
—
Volume of the periodical
19
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
734-747
UT code for WoS article
000332485700015
EID of the result in the Scopus database
—