Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-thereapeutic perspectives
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F14%3A10209641" target="_blank" >RIV/00216208:11150/14:10209641 - isvavai.cz</a>
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs11011-013-9428-9" target="_blank" >http://link.springer.com/article/10.1007%2Fs11011-013-9428-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11011-013-9428-9" target="_blank" >10.1007/s11011-013-9428-9</a>
Alternative languages
Result language
angličtina
Original language name
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-thereapeutic perspectives
Original language description
The article provides evidence that a vicious cycle in glutamine synthesis and breakdown among tissues with high levels of glutamine synthetase (skeletal muscle, brain) and glutaminase (enetrocytes, kidneys) is activated in liver failure. These alterations may explain why therapies targeted to intestinal bacteria have only a limited effect on ammonia levels in patients with liver failure and indicate the needs of new therapeutic strategies focused on glutamine metabolism. The positive and adverse effectsof various nutritional and pharmacological strategies focused on glutamine metabolism in treatment of hyperammonemia and hepatice encephalopathy are discussed in the second part of the article. Attention is given to glutamine, glutamate, alpha-ketoglutarate, branched-chain amino acids, glutaminase inhibitors, and phenylbutyrate.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Metabolic Brain Disease
ISSN
0885-7490
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
9-17
UT code for WoS article
000331965900002
EID of the result in the Scopus database
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