Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement. Molecular analysis of 94 salivary gland carcinomas with prominent clear cell component

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10294673" target="_blank" >RIV/00216208:11150/15:10294673 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/15:10294673 RIV/00216208:11140/15:10294673
Result on the web
<a href="http://dx.doi.org/10.1097/PAS.0000000000000364" target="_blank" >http://dx.doi.org/10.1097/PAS.0000000000000364</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAS.0000000000000364" target="_blank" >10.1097/PAS.0000000000000364</a>

Result language
angličtina
Original language name
Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement. Molecular analysis of 94 salivary gland carcinomas with prominent clear cell component
Original language description
This study examines the presence of the EWSR1 rearrangement in a variety of clear cell salivary gland carcinomas with myoepithelial differentiation. A total of 94 salivary gland carcinomas with a prominent clear cell component included 51 cases of clearcell myoepithelial carcinomas de novo (CCMC), 21 cases of CCMCs ex pleomorphic adenoma (CCMCexPA), 11 cases of epithelial-myoepithelial carcinoma (EMC), 6 cases of EMC with solid clear cell overgrowth, and 5 cases of hyalinizingclear cell carcinoma of minor salivary glands. In addition, 10 cases of myoepithelial carcinomas devoid of clear cell change and 12 cases of benign myoepithelioma were included as well. All the tumors in this spectrum were reviewed, reclassified, and tested by fluorescence in situ hybridization (FISH) for the EWSR1 rearrangement using the Probe Vysis EWSR1 Break Apart FISH Probe Kit. The EWSR1 rearrangement was detected in 20 of 51 (39%) cases of CCMC, in 5 of 21 (24%) cases of CCMCexPA, in 1 of 11 (9%) cases of
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/NT13701" target="_blank" >NT13701: Expression of vascular endothelial growth factor VEGF-C/D and its significance for lymphangioneogenesis, nodal metastase and prognosis of salivary gland carcinomas.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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