CD73 Plays a Protective Role in Collagen-Induced Arthritis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10301787" target="_blank" >RIV/00216208:11150/15:10301787 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/15:10301787
Result on the web
<a href="http://dx.doi.org/10.4049/jimmunol.1401416" target="_blank" >http://dx.doi.org/10.4049/jimmunol.1401416</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4049/jimmunol.1401416" target="_blank" >10.4049/jimmunol.1401416</a>

Result language
angličtina
Original language name
CD73 Plays a Protective Role in Collagen-Induced Arthritis
Original language description
Article discusses the sensitivity of CD73-deficient mice to collagen-induced arthritis. We demonstrated that CD73, which participates in the formation of extracellular adenosine, plays a protective role in the development of collagen-induced arthritis (CIA). Modulation of adenosine signaling is a promising new approach for treatment of RA. Our study provides the first evidence that CD73 expression is a homeostatic mechanism that downmodulates joint inflammation. Our data also confirm the protective roleof the A2A adenosin receptor in CIA in addition to the established protective role of the adenosine A3 receptor in this disease. Modulation of the CD 73-adenosinergic pathway may thus constitute a promising approach for tteatment of RA.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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