Collagen matrix as a tool in studying fibroblastic cell behavior

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10306855" target="_blank" >RIV/00216208:11150/15:10306855 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1080/19336918.2015.1005469" target="_blank" >http://dx.doi.org/10.1080/19336918.2015.1005469</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/19336918.2015.1005469" target="_blank" >10.1080/19336918.2015.1005469</a>

Result language
angličtina
Original language name
Collagen matrix as a tool in studying fibroblastic cell behavior
Original language description
Type I collagen is a fibrillar protein, a member of a large family of collagen proteins. It is present in most body tissues, usually in combination with other collagens and other components of extracellular matrix. Its synthesis is increased in various pathological situations, in healing wounds, in fibrotic tissues and in many tumors. After extraction from collagen-rich tissues it is widely used in studies of cell behavior, especially those of fibroblasts and myofibroblasts. Cells cultured in a classical way, on planar plastic dishes, lack the third dimension that is characteristic of body tissues. Collagen I forms gel at neutral pH and may become a basis of a 3D matrix that better mimics conditions in tissue than plastic dishes.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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