Potential Anti-cancer Drugs Commonly Used for Other Indications

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10312036" target="_blank" >RIV/00216208:11150/15:10312036 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/15:10312036
Result on the web
<a href="http://benthamscience.com/journals/current-cancer-drug-targets/volume/15/issue/1/page/35/" target="_blank" >http://benthamscience.com/journals/current-cancer-drug-targets/volume/15/issue/1/page/35/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1568009615666141229152812" target="_blank" >10.2174/1568009615666141229152812</a>

Result language
angličtina
Original language name
Potential Anti-cancer Drugs Commonly Used for Other Indications
Original language description
An increasing resistance of mammalian tumor cells to chemotherapy along with the severe side effects of commonly used cytostatics has raised the urgency in the search for new anti-cancer agents. Several drugs originally approved for indications other than cancer treatment have recently been found to have a cytostatic effect on cancer cells. These drugs could be expediently repurposed as anti-cancer agents, since they have already been tested for toxicity in humans and animals. The groups of newly recognized potential cytostatics discussed in this review include benzimidazole anthelmintics (albendazole, mebendazole, flubendazole), anti-hypertensive drugs (doxazosin, propranolol), psychopharmaceuticals (chlorpromazine, clomipramine) and antidiabetic drugs (metformin, pioglitazone). All these drugs have a definite potential to be used especially in combinations with other cytostatics; the chemotherapy targeting of multiple sites now represents a promising approach in cancer treatment. The
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—

Project
<a href="/en/project/EE2.3.30.0022" target="_blank" >EE2.3.30.0022: Support of establishment, development, and mobility of quality research teams at the Charles University</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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