Comparative study of various subpopulations of cytotoxic cells in blood and ascites from patients with ovarian carcinoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10312145" target="_blank" >RIV/00216208:11150/15:10312145 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/15:10312145

Result on the web

<a href="http://www.termedia.pl/Journal/-3/Streszczenie-25814" target="_blank" >http://www.termedia.pl/Journal/-3/Streszczenie-25814</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5114/wo.2015.54388" target="_blank" >10.5114/wo.2015.54388</a>

Result language

angličtina

Original language name

Comparative study of various subpopulations of cytotoxic cells in blood and ascites from patients with ovarian carcinoma

Original language description

A number of observations indicate that the immune system plays a significant role in patients with epithelial ovarian cancer (EOC). In case of EOC the prognostic significance of tumour infiltrating lymphocytes, (TILs) has not been obviously explained yet. The aim is to determine the phenotype and activation molecule of cytotoxic T cells and NK cells subpopulations and to compare their representation in malignant ascites and peripheral blood (PBL) in patients with ovarian cancer. The cytotoxic cells taken from blood samples of the cubital vein and malignant ascites were obtained from 53 patients with EOC. Their surface and activation characteristics were determined by means of a flow cytometer. Immunophenotype multiparametric analysis of PBL and TILs was carried out. CD3+ T lymphocytes were the main population of TILs (75.9%) and PBL (70.9%). The number of activating T cells was significantly higher in TILs, CD3+/69+ 6.7% vs.0.8% (p<0.001). The representation of (CD3-/16+56+) NK cells i

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Wspolczesna Onkologia

ISSN

1428-2526

e-ISSN

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Volume of the periodical

19

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

10

Pages from-to

290-299

UT code for WoS article

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EID of the result in the Scopus database

2-s2.0-84942605792