Boldine enhances bile production in rats via osmotic and Farnesoid X receptor dependent mechanisms

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10312485" target="_blank" >RIV/00216208:11150/15:10312485 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/15:10312485
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0041008X15000861" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0041008X15000861</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.taap.2015.03.004" target="_blank" >10.1016/j.taap.2015.03.004</a>

Result language
angličtina
Original language name
Boldine enhances bile production in rats via osmotic and Farnesoid X receptor dependent mechanisms
Original language description
Boldine, the major alkaloid from the Chilean Boldo tree, is used in traditional medicine to support bile production, but evidence to support this function is controversial. We analyzed the choleretic potential of boldine, including its molecular background. The acute- and long-term effects of boldine were evaluated in rats either during intravenous infusion or after 28-day oral treatment. Infusion of boldine instantly increased the bile flow 1.4-fold in healthy rats as well as in animals with Mrp2 deficiency or ethinylestradiol induced cholestasis. This effect was not associated with a corresponding increase in bile acid or glutathione biliary excretion, indicating that the effect is not related to stimulation of either bile acid dependent or independent mechanisms of bile formation and points to the osmotic activity of boldine itself. We subsequently analyzed bile production under conditions of changing biliary excretion of boldine after bolus intravenous administration and found stro
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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