The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10314760" target="_blank" >RIV/00216208:11150/15:10314760 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/15:43875431 RIV/00179906:_____/15:10314760
Result on the web
<a href="http://dx.doi.org/10.1016/j.jab.2015.04.004" target="_blank" >http://dx.doi.org/10.1016/j.jab.2015.04.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jab.2015.04.004" target="_blank" >10.1016/j.jab.2015.04.004</a>

Result language
angličtina
Original language name
The effect of different doses of atropine on gastric myoelectrical activity in fasting experimental pigs
Original language description
Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. There are no data on the impact of moderate to high doses of atropine on EGG, neither in humans nor experimental pigs. The purpose of this study was to evaluate the effect of different doses of atropine on EGG in experimental pigs. Six fasting pigs entered the study three times in a random order. The baseline EGG recording lasted 20 min, followed by a 105-minEGG trial recording. Intramuscular atropine 1.5 mg (part 1), 3.0 mg (part 2) and 4.5 mg (part 3) was administrated after the baseline EGG. Atropine doses of 1.5 and 3.0 mg revealed a similar pattern in the EGG power course. After an initial increase (atthe first 15-min interval), the areas of amplitudes decreased back to values comparable with basal levels and subsequently increased significantly again to the maximum at 105 min. The EGG power was quite different after the administratio
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Project
<a href="/en/project/NT14270" target="_blank" >NT14270: Pharmacokinetics and gastrointestinal motor effects of novel acetylcholinesterase modulators in experimental pigs</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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