Immunoparesis in MGUS - Relationship of uninvolved immunoglobulin pair suppression and polyclonal immunoglobuline levels to MGUS risk categories

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10315543" target="_blank" >RIV/00216208:11150/15:10315543 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/15:00063495 RIV/00179906:_____/15:10315543 RIV/00098892:_____/15:#0000959 RIV/00843989:_____/15:E0104857 RIV/61989592:15110/15:33157120

Result on the web

<a href="http://dx.doi.org/10.4149/neo_2015_100" target="_blank" >http://dx.doi.org/10.4149/neo_2015_100</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2015_100" target="_blank" >10.4149/neo_2015_100</a>

Result language

angličtina

Original language name

Immunoparesis in MGUS - Relationship of uninvolved immunoglobulin pair suppression and polyclonal immunoglobuline levels to MGUS risk categories

Original language description

Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic, potentially malignant condition. It has been established that annually approximately 1-2% of MGUS cases transforms into one of the malignant forms of monoclonal gammopathies. Progression risk factors include the quantity and type of M-protein, and namely the ratio of free light immunoglobulin chains (FLC). These factors, enable purposeful stratification of MGUS individuals. Some authors consider suppression of polyclonal immunoglobulin levels to be another progression factor. The aim of the study was to compare polydonal immunoglobulin (PIg) levels with uninvolved heavy/light chain pair (HLC) levels in order to verify the degree of immunoparesis depending on MGUS risk category (0-3). The analyzed set consisted of 159 serum samples from MGUS patients (102 IgG, 57 IgA), who were stratified into 4 risk groups (0 low, 1 low-intermediate, 2 high-intermediate and 3 high risk of transformation). The results of analy

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neoplasma

ISSN

0028-2685

e-ISSN

—

Volume of the periodical

62

Issue of the periodical within the volume

5

Country of publishing house

SK - SLOVAKIA

Number of pages

6

Pages from-to

827-832

UT code for WoS article

000362389600019

EID of the result in the Scopus database

2-s2.0-84943638662