The complex etiology of schizophrenia - general state of the art

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F15%3A10322289" target="_blank" >RIV/00216208:11150/15:10322289 - isvavai.cz</a>

Alternative codes found

RIV/47813059:19510/15:#0000583 RIV/00179906:_____/15:10322289

Result on the web

<a href="http://www.nel.edu/archive_issues/o/36_7/36_7_Hosak_631-637.pdf" target="_blank" >http://www.nel.edu/archive_issues/o/36_7/36_7_Hosak_631-637.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The complex etiology of schizophrenia - general state of the art

Original language description

The etiology of schizophrenia is complex. The aim of this article is to present a global view of the causes of schizophrenia and their interconnectivity. Recent genetic research into schizophrenia is based on genome-wide association studies, the assessment of DNA copy number variations, and the concept of endophenotypes. A lot of suspected genes have already been identified, mostly relating to neurodevelopment, neuroplasticity, immunology and neuroendocrinology. Gene-environment interactions (GxE) reflect genetic variation in susceptibility to the environment. Psychosocial stress and cannabis abuse seem to be the most important environmental factors in schizophrenia etiology. Epigenetic mechanisms, particularly DNA methylation, histone modifications, and non-coding RNAs are the most important linking factor among the genetic and prenatal environmental variables in the etiology of schizophrenia. Postnatal risk factors (e.g., stress, urbanicity, cannabis use) may also affect the risk of

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Volume of the periodical

36

Issue of the periodical within the volume

7

Country of publishing house

SE - SWEDEN

Number of pages

7

Pages from-to

631-637

UT code for WoS article

000370969000001

EID of the result in the Scopus database

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