Antiproliferative effects of α-tomatine are associated with different cell death modalities in human colon cancer cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F16%3A10328502" target="_blank" >RIV/00216208:11150/16:10328502 - isvavai.cz</a>
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1756464616303188" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1756464616303188</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jff.2016.10.005" target="_blank" >10.1016/j.jff.2016.10.005</a>
Alternative languages
Result language
angličtina
Original language name
Antiproliferative effects of α-tomatine are associated with different cell death modalities in human colon cancer cells
Original language description
Antitumour effects of α-tomatine were studied during 24 hours in a panel of human colon cancer cells. α-Tomatine proved to induce dose-dependent cytotoxicity resulting in morphologically varying cell demise with predominantly occurring necrotic phenotypes and minor presence of cells dying via caspase-independent apoptosis. Analyses into the nature of mechanisms responsible for activation of cell death revealed that following α-tomatine treatment, changes in RIP3 and RIP1 protein expression take place along with cyclophilin D mitochondrial accumulation. Moreover, in treated cells, lysosomal membrane permeabilization as well as mitochondrial perturbation with subsequent mitochondrial release of apoptosis-inducing factor (AIF) contributes to the execution of diverse death phenotypes possibly via enhanced activity JNK but in the absence of significant oxidative stress. Thus α-tomatine exhibits significant antitumour activity in colon cancer cells via targeting their membranous compartments and inducing both necroptosis and apoptosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Functional Foods
ISSN
1756-4646
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
December
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
12
Pages from-to
491-502
UT code for WoS article
000390180000043
EID of the result in the Scopus database
2-s2.0-84994043931