Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10365265" target="_blank" >RIV/00216208:11150/17:10365265 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/17:10365265
Result on the web
<a href="http://dx.doi.org/10.1186/s40463-017-0228-9" target="_blank" >http://dx.doi.org/10.1186/s40463-017-0228-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s40463-017-0228-9" target="_blank" >10.1186/s40463-017-0228-9</a>
Alternative languages
Result language
angličtina
Original language name
Rheopheresis in treatment of idiopathic sensorineural sudden hearing loss
Original language description
Backround: Only few therapeutic options exist for patients with refractory sudden idiopathic sensorineural hearing loss (SISHL). Little is known about the efficacy of second-line therapies. Rheopheresis seems to be an effective therapeutic possibility. Methods: Between 2012 and 2015, 106 patients with SISHL were enrolled in the study, of whom 52 were refractory to initial treatment. As salvage therapy, these patients were offered either 3 sessions of rheopheresis (33 pts) or intratympanic steroid treatment through MicroWick application (19 pts). Pure tone audiometry was performed at diagnosis, at the 1st month and the 1st year during the follow-up. Results: Patients in the rheopheretic arm had higher hearing loss than in the MicroWick arm (81% vs. 52%, p = 0.04). In spite of this, there was a significant improvement for patients in the rheopheretic arm (27% of hearing loss reduction, p < 0.001) after the 1st month and this remained unchanged during the 1st year, while no improvement was seen in the MicroWick arm (0% of hearing loss reduction, p = 0.424). We found no predictive factor for steroid-failure in first-line therapy. Older age (p = 0.003), presence of vertigo (p = 0.006) and more profound initial hearing loss (p < 0.001) were identified as negative prognostic markers. Conclusion: Rheopheresis can be used as a potentially effective and safe salvage therapy for patients with cortico-refractory SISHL.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Otolaryngology - Head and Neck Surgery
ISSN
1916-0216
e-ISSN
—
Volume of the periodical
46
Issue of the periodical within the volume
June
Country of publishing house
CA - CANADA
Number of pages
7
Pages from-to
—
UT code for WoS article
000404678500001
EID of the result in the Scopus database
2-s2.0-85021644601