Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10368164" target="_blank" >RIV/00216208:11150/17:10368164 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/17:10368164 RIV/00179906:_____/17:10368164 RIV/61989592:15110/17:73583797 RIV/61989592:15310/17:73583797
Result on the web
<a href="http://www.degruyter.com/view/j/pteridines.2017.28.issue-3-4/pterid-2017-0005/pterid-2017-0005.xml" target="_blank" >http://www.degruyter.com/view/j/pteridines.2017.28.issue-3-4/pterid-2017-0005/pterid-2017-0005.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/pterid-2017-0005" target="_blank" >10.1515/pterid-2017-0005</a>
Alternative languages
Result language
angličtina
Original language name
Comparison of performance of composite biomarkers of inflammatory response in determining the prognosis of breast cancer patients
Original language description
In the present study, we determined complex indices of inflammatory activity and compared the performance of these indices as prognostic biomarkers in a cohort of breast cancer patients. All proposed composite biomarkers could be evaluated in 418 out of 474 patients in the cohort with complete data on peripheral blood cell count, urinary neopterin, albumin and C-reactive protein. Neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, platelet-to-lymphocyte ratio, systemic inflammatory index, Glasgow prognostic index, modified Glasgow prognostic index, prognostic nutritional index and C-reactive protein/albumin ratio were calculated and further complex indices were proposed. Although a number of the investigated indices were significantly associated with survival in the univariate analysis, only age and stage, but none of the laboratory biomarkers or composite biomarkers, were significant predictors of survival in the whole group in the multivariate analysis. In patients evaluated before the start of the treatment, age, stage and urinary neopterin were significant predictors of survival. These results underscore the importance of neopterin as a prognostic biomarker in breast cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
<a href="/en/project/NV16-32030A" target="_blank" >NV16-32030A: Repurposing disulfiram as a novel treatment for chemo-endocrine therapy-resistant, recurrent metastatic breast cancer</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Pteridines
ISSN
0933-4807
e-ISSN
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Volume of the periodical
28
Issue of the periodical within the volume
3-4
Country of publishing house
DE - GERMANY
Number of pages
8
Pages from-to
213-220
UT code for WoS article
000416827700012
EID of the result in the Scopus database
2-s2.0-85038004175