Hyperglycemia During Home Parenteral Nutrition Administration in Patients Without Diabetes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10368317" target="_blank" >RIV/00216208:11150/17:10368317 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1177/0148607115606116" target="_blank" >http://dx.doi.org/10.1177/0148607115606116</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/0148607115606116" target="_blank" >10.1177/0148607115606116</a>

Result language

angličtina

Original language name

Hyperglycemia During Home Parenteral Nutrition Administration in Patients Without Diabetes

Original language description

Background: Parenteral nutrition (PN) is a life-sustaining therapy in appropriate clinical settings. In the hospital setting, some nondiabetic patients develop hyperglycemia and subsequently require long-term insulin while receiving PN. Whether similar hyperglycemia is seen in the outpatient setting is unclear. Methods: We studied patients enrolled in the Mayo Clinic Home Parenteral Nutrition (HPN) program between January 1, 2010, and December 31, 2012. Patients were excluded if they had diabetes mellitus type 2 (DM2), had previously received HPN, had taken corticosteroids, or were at risk for refeeding syndrome. Results: Of 144 enrolled patients, 93 met inclusion criteria with 39 patients requiring the addition of insulin to HPN. The mean age of the insulin-requiring group (IR) was higher than that of the non-insulin-requiring group (NIR) (60.74 +/- 13.62 years vs 48.97 +/- 17.62 years, P &lt; .001). There were 17 (44%) men in the IR group and 26 (48%) men in the NIR group. Mean blood glucose at baseline before starting the infusion was 131.82 +/- 49.55 mg/dL in IR patients and 106.16 +/- 59.01 mg/dL in NIR patients (P = .03). In the stepwise multivariate analysis for assessing the risk for developing hyperglycemia, HR for age was 1.020 (1.010-1.031), P &lt; .001. Conclusions: Hyperglycemia is a common finding with the use of PN in both the hospital and ambulatory setting in patients without a previous diagnosis of DM2. Age was the most significant predictor of the requirement of insulin in the present study. When hyperglycemia is managed appropriately with insulin therapy, the long-term complications can be minimized.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30308 - Nutrition, Dietetics

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Parenteral and Enteral Nutrition

ISSN

0148-6071

e-ISSN

—

Volume of the periodical

41

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

672-677

UT code for WoS article

000400297600022

EID of the result in the Scopus database

2-s2.0-85018756071