Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F17%3A10371691" target="_blank" >RIV/00216208:11150/17:10371691 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/17:10371691
Result on the web
<a href="http://dx.doi.org/10.1177/0267659116669586" target="_blank" >http://dx.doi.org/10.1177/0267659116669586</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1177/0267659116669586" target="_blank" >10.1177/0267659116669586</a>
Alternative languages
Result language
angličtina
Original language name
Effects of conventional CPB and mini-CPB on neutrophils CD162, CD166 and CD195 expression
Original language description
Objective: Cardiac surgery is known to trigger a systemic inflammatory response. While the use of conventional cardiopulmonary bypass (CPB) results in profound inflammation, modified mini-CPB is considered less harmful. We evaluated the impact of cardiac surgery on the expression of CD162, CD166, CD195 molecules and their association with the type of CPB used. Methods and Results: Twenty-four patients were enrolled in our study. Twelve of them were operated using conventional CPB while the other twelve patients underwent surgery with mini-CPB. Blood samples were analysed by flow cytometry. We observed a significant increase in median fluorescence intensity of CD162 and CD195 that peaked instantly after surgery and normalized to the baseline value on the 1(st) day post surgery, whereas CD166 was initially down-regulated and its median fluorescence intensity (MFI) value increased to the baseline in the next few days. Conclusion: We observed immediate changes in the expression of CD162, CD166, and CD195 molecules on the neutrophils after surgery in both study groups of patients. The intensity of the observed changes was significantly greater in the group of patients who underwent conventional CPB compared to patients who underwent mini-CPB cardiac surgery.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Perfusion
ISSN
0267-6591
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
141-150
UT code for WoS article
000394654100009
EID of the result in the Scopus database
2-s2.0-85012077965