Mast cells in calcific aortic stenosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10368523" target="_blank" >RIV/00216208:11150/18:10368523 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/18:10368523
Result on the web
<a href="http://dx.doi.org/10.1016/j.prp.2017.07.016" target="_blank" >http://dx.doi.org/10.1016/j.prp.2017.07.016</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.prp.2017.07.016" target="_blank" >10.1016/j.prp.2017.07.016</a>

Result language
angličtina
Original language name
Mast cells in calcific aortic stenosis
Original language description
In developed countries, calcific aortic stenosis(CAS) has become the most common acquired valvular disease and reason for aortic valve replacement. It is considered a form of atherosclerosis, like the latter, of inflammatory origin, with presence in the calcified aortic valves of blood vessels, lymphatics, lymphocytes, plasma cells, histiocytes, and sometimes also of metaplastic bone tissue. This study is aimed at examining the presence of CD117 - positive mast cells in CAS. In 56 examined calcified aortic valves excised by cardiac surgery, mast cells were constantly present as a part of the polymorphous cellular infiltrate; in individual cases, their numbers were 1-90 (median 24). The numbers were significantly higher in the congenitally malformed/biscupid valves (median 40) than in the tricuspid ones (median 20). In valves with presence of metaplastic bone, mast cells were significantly more numerous (median 42) than in those without metaplasia (median 20). In 12 normal aortic valves obtained at autopsies, the numbers of mast cells were 4-21 (median 11). Discussed is a possible role of mast cells in pathogenesis of CAS.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems

Project
<a href="/en/project/LM2015089" target="_blank" >LM2015089: Bank of Clinical Specimens</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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