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Covariate determinants of effective dosing regimens for time-dependent beta-lactam antibiotics for critically ill patients

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10376542" target="_blank" >RIV/00216208:11150/18:10376542 - isvavai.cz</a>

  • Alternative codes found

    RIV/00179906:_____/18:10376542

  • Result on the web

    <a href="http://biomed.papers.upol.cz/pdfs/bio/2018/03/09.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2018/03/09.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2018.011" target="_blank" >10.5507/bp.2018.011</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Covariate determinants of effective dosing regimens for time-dependent beta-lactam antibiotics for critically ill patients

  • Original language description

    Critically ill patients undergoing aggressive fluid resuscitation and treated empirically with hydrosoluble time-dependent beta-lactam antibiotics are at risk for sub-therapeutic plasma concentrations. The aim of this study was to assess the impact of two covariates - creatinine clearance (Clcr) and cumulative fluid balance (CFB) on PK/PD target attainment within a week of treatment with meropenem (ME) or piperacillin/tazobactam (PIP/TZB). Assuming that the positive correlation between CFB and Vd exists for piperacillin in the pathological setting, then CFB should predict Vd across subjects at each and every time point. The authors recommend to use two times higher starting dose of piperacilin/tazobactam and 100 %f T &gt; 4 MIC for PK/PD target attainment in critically ill patient undergoing aggressive fluid resuscitation than in standard type of patient.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30212 - Surgery

Result continuities

  • Project

    <a href="/en/project/NT14089" target="_blank" >NT14089: Personalized antibiotic therapy in surgical patients with heavy bacterial infection and important sequestration of liquids.</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedical Papers

  • ISSN

    1213-8118

  • e-ISSN

  • Volume of the periodical

    162

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    8

  • Pages from-to

    219-226

  • UT code for WoS article

    000445913000009

  • EID of the result in the Scopus database

    2-s2.0-85053726536