Covariate determinants of effective dosing regimens for time-dependent beta-lactam antibiotics for critically ill patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10376542" target="_blank" >RIV/00216208:11150/18:10376542 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/18:10376542
Result on the web
<a href="http://biomed.papers.upol.cz/pdfs/bio/2018/03/09.pdf" target="_blank" >http://biomed.papers.upol.cz/pdfs/bio/2018/03/09.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2018.011" target="_blank" >10.5507/bp.2018.011</a>
Alternative languages
Result language
angličtina
Original language name
Covariate determinants of effective dosing regimens for time-dependent beta-lactam antibiotics for critically ill patients
Original language description
Critically ill patients undergoing aggressive fluid resuscitation and treated empirically with hydrosoluble time-dependent beta-lactam antibiotics are at risk for sub-therapeutic plasma concentrations. The aim of this study was to assess the impact of two covariates - creatinine clearance (Clcr) and cumulative fluid balance (CFB) on PK/PD target attainment within a week of treatment with meropenem (ME) or piperacillin/tazobactam (PIP/TZB). Assuming that the positive correlation between CFB and Vd exists for piperacillin in the pathological setting, then CFB should predict Vd across subjects at each and every time point. The authors recommend to use two times higher starting dose of piperacilin/tazobactam and 100 %f T > 4 MIC for PK/PD target attainment in critically ill patient undergoing aggressive fluid resuscitation than in standard type of patient.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30212 - Surgery
Result continuities
Project
<a href="/en/project/NT14089" target="_blank" >NT14089: Personalized antibiotic therapy in surgical patients with heavy bacterial infection and important sequestration of liquids.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
162
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
219-226
UT code for WoS article
000445913000009
EID of the result in the Scopus database
2-s2.0-85053726536