Multiplex biomarker approach to cardiovascular diseases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10377646" target="_blank" >RIV/00216208:11150/18:10377646 - isvavai.cz</a>

Result on the web

<a href="https://www.nature.com/articles/aps201829" target="_blank" >https://www.nature.com/articles/aps201829</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/aps.2018.29" target="_blank" >10.1038/aps.2018.29</a>

Result language

angličtina

Original language name

Multiplex biomarker approach to cardiovascular diseases

Original language description

Personalized medicine is partly based on biomarker-guided diagnostics, therapy and prognosis, which is becoming an unavoidable concept in modern cardiology. However, the clinical significance of single biomarker studies is rather limited. A promising novel approach involves combining multiple markers into a multiplex panel, which could refine the management of a particular patient with cardiovascular pathology. Two principally different assay formats have been developed to facilitate simultaneous quantification of multiple antigens: planar array assays and microbead assays. These approaches may help to better evaluate the complexity and dynamic nature of pathologic processes and offer substantial cost and sample savings compared with traditional enzyme-linked immunosorbent assay (ELISA) measurements. However, a multiplex multimarker approach cannot become a generally disseminated method until analytical problems are solved and further studies confirming improved clinical outcomes are accomplished. These drawbacks underlie the fact that a limited number of systematic studies are available regarding the use of a multiplex biomarker approach in cardiovascular medicine to date. Our perspective underscores the significant potential of the use of the multiplex approach in a wider conceptual framework under the close cooperation of clinical and experimental cardiologists, pathophysiologists and biochemists so that the personalized approach based on standardized multimarker testing may improve the management of various cardiovascular pathologies and become a ubiquitous partner of population-derived evidence-based medicine.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Pharmacologica Sinica

ISSN

1671-4083

e-ISSN

—

Volume of the periodical

39

Issue of the periodical within the volume

7

Country of publishing house

CN - CHINA

Number of pages

5

Pages from-to

1068-1072

UT code for WoS article

000438943200002

EID of the result in the Scopus database

2-s2.0-85050309276