Boldine Does Not Modify Gender Specific Wound Healing in Zucker Diabetic Rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F18%3A10385100" target="_blank" >RIV/00216208:11150/18:10385100 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Boldine Does Not Modify Gender Specific Wound Healing in Zucker Diabetic Rats
Original language description
Boldine is a natural alkaloid with anti-inflammatory and antioxidant effects. It reduces glycemia and decreases blood pressure in rats with type 1 diabetes. We have also studied whether boldine has anti-inflammatory and antioxidant effects in rats with type 2 diabetes and whether it can improve healing of their skin wounds, a serious comorbidity of type 2 diabetes. This work also compares lean and obese Zucker diabetic rats, including a comparison of both sexes. After skin excisions, the wounded animals received granules containing boldine ad libitum. The weights of rats, amount of consumed food and wound size were measured regularly. Scar and internal organs were removed and analyzed. Further, the tensile strength of the scar was tested and hydroxyproline content (a marker of collagen) measured. We have not confirmed previously published positive effects of boldine, but we observed important differences between gender and between genotypes. Male rats had higher body weight, liver, kidney and spleen than female rats. Furthermore, their wounds took longer to heal with bigger scar areas.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Natural Product Communications
ISSN
1934-578X
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
3
Pages from-to
1475-1477
UT code for WoS article
000456230000016
EID of the result in the Scopus database
2-s2.0-85057800354