Molecular and Ultrastructural Features of Diffuse Intrapulmonary Malignant Mesothelioma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F19%3A10496872" target="_blank" >RIV/00216208:11150/19:10496872 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lW3BHUEDRo" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lW3BHUEDRo</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/PAS.0000000000001143" target="_blank" >10.1097/PAS.0000000000001143</a>
Alternative languages
Result language
angličtina
Original language name
Molecular and Ultrastructural Features of Diffuse Intrapulmonary Malignant Mesothelioma
Original language description
Diffuse malignant mesothelioma of the pleura typically presents with a pleural effusion and diffuse growth along pleural surfaces, producing a thickened pleura and pleural-based masses that can encase the lung in a thick rind. Diffuse involvement of the underlying pulmonary parenchyma without significant pleural disease is rare.Histopathologic confirmation of the diagnosis is usually not difficult, but when mesothelioma presents with a more unusual clinical or radiologic pattern of disease, its diagnosis can be more challenging. We recently reported 5 cases of diffuse intrapulmonary malignant mesothelioma (DIMM), a rare variant of mesothelioma with a distinctive pattern of predominantly intrapulmonary growth and minimal pleural involvement that clinically and radiologically simulates interstitial lung disease. To our knowledge, this remains the largest series to date of this peculiar phenomenon, but DIMM remains poorly understood. Understandably, some have questioned whether DIMM is truly mesotheliomatous, as its behavior and growth patterns are admittedly very unusual for a mesothelioma and its putative mesothelial nature has been based entirely on its morphologic and immunophenotypic features. To date, its molecular and ultrastructural characteristics have never been evaluated, prompting this communication.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30109 - Pathology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Surgical Pathology
ISSN
0147-5185
e-ISSN
1532-0979
Volume of the periodical
43
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
147-150
UT code for WoS article
000454300400016
EID of the result in the Scopus database
2-s2.0-85052926828