Salivary gland function in thyroid cancer patients with radioiodine administration history

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F20%3A10399105" target="_blank" >RIV/00216208:11150/20:10399105 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/20:10399105

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=CTs5VxhMgq" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=CTs5VxhMgq</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2019.023" target="_blank" >10.5507/bp.2019.023</a>

Result language

angličtina

Original language name

Salivary gland function in thyroid cancer patients with radioiodine administration history

Original language description

AIM:Radioiodine (RAI) improves survival in patients with locally advanced or metastatic differentiated thyroid carcinoma (DTC). Although there has been an ongoing debate on RAI-induced salivary gland damage, published data have been inconsistent. Therefore, the purpose of our study was to compare salivary gland function in intermediate and high risk DTC patients after single or repeated RAI treatment with their age- and sex-matched RAI-naive counterparts.METHODS:Uptake and excretion of parotid and submandibular glands were quantitatively evaluated using 99mTc-pertechnetate salivary gland scintigraphy in 23 patients previously treated with RAI. Patients (median 9.25 GBq 131I-NaI; Q1-Q3: 5.55-16.65; range: 5.55-27.5) were divided into subgroups according to previously administered 131I-NaI activity using cut-off values 5.55 GBq and 9.25 GBq. Their salivary gland scintigraphy results were compared with RAI-naive patients using Mann-Whitney test.RESULTS:Compared to RAI-naive patients, parotid glands pertechnetate uptake was significantly lower in those treated with &gt; 9.25 GBq (P=0.034) and parotid glands excretion fraction was already decreased with RAI activities &gt; 5.55 GBq (P=0.031). In submandibular glands, no statistically significant difference in either function was observed even with RAI activity &gt; 9.25 GBq.CONCLUSION:Our data suggest that RAI therapy using activities &lt;= 5.55 GBq does not substantially decrease saliva production. Activities &gt; 5.55 GBq may lead to significant decrease in parotid excretion, and activities &gt; 9.25 GBq also diminish parotid uptake. Surprisingly, submandibular glands, providing majority of seromucinous saliva under basal condition, seem to be unaffected even by RAI activities above 9.25 GBq.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

164

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

277-283

UT code for WoS article

000595645600009

EID of the result in the Scopus database

2-s2.0-85091166799