Infliximab plus azathioprine is more effective than azathioprine alone in achieving mucosal healing in pediatric patients with Crohn's disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F20%3A10419563" target="_blank" >RIV/00216208:11150/20:10419563 - isvavai.cz</a>
Alternative codes found
RIV/00179906:_____/20:10419563
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_J0Wpo6Jac" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_J0Wpo6Jac</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/1751-2980.12927" target="_blank" >10.1111/1751-2980.12927</a>
Alternative languages
Result language
angličtina
Original language name
Infliximab plus azathioprine is more effective than azathioprine alone in achieving mucosal healing in pediatric patients with Crohn's disease
Original language description
Objectives Over the past few years, mucosal healing (MH) has emerged as a promising goal in the treatment of pediatric patients with Crohn's disease (CD). We aimed to assess whether combination therapy with infliximab (IFX) + azathioprine (AZA) was more effective than AZA therapy alone in achieving mucosal healing in pediatric patients with CD. Methods Newly diagnosed pediatric patients with CD at the Department of Pediatrics in University Hospital in Hradec Kralove were retrospectively recruited (2000-2014). The patients were divided into two groups according to the therapy: (a) IFX + AZA +/- corticosteroids +/- 5-aminosalicylic acid (5-ASA) (n = 16); and (b) AZA +/- corticosteroids +/- 5-ASA (n = 40). The patients were also divided into two groups: "MH" and "no MH," according to their MH status. MH was defined as the complete endoscopic disappearance of all mucosal ulcerations (including aphthous ulcerations) and the absence of any sign of mucosal inflammation in the terminal ileum and the large bowel. Results Of 56 patients, MH was observed in 56% (9/16) treated with combined therapy in comparison with 15% (6/40) of patients in the AZA group (P = 0.006). The median dose of AZA in both groups was 2.1 mg/kg per day. We observed eight adverse events in seven patients from the IFX + AZA group. Adverse effects were less common in the AZA group (P = 0.002). Conclusion Combined therapy (IFX + AZA) was more effective in achieving MH in pediatric CD than treatment with AZA alone.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Digestive Diseases
ISSN
1751-2972
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
12
Country of publishing house
CN - CHINA
Number of pages
6
Pages from-to
705-710
UT code for WoS article
000594995500004
EID of the result in the Scopus database
2-s2.0-85097054205