Histopathological changes in dilated ascending aorta associated with aortic valve cuspidity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10419041" target="_blank" >RIV/00216208:11150/21:10419041 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/21:10419041

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JmjKWnx.UP" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JmjKWnx.UP</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ejcts/ezaa440" target="_blank" >10.1093/ejcts/ezaa440</a>

Result language

angličtina

Original language name

Histopathological changes in dilated ascending aorta associated with aortic valve cuspidity

Original language description

Abstract Objectives: Patients with a bicuspid aortic valve (BAV) often present with a dilated ascending aorta. However, the underlying pathogenesis for the observed changes in the aortic wall and the resulting aneurysmal dilation remains a subject of debate. This study aims to compare the histological abnormalities of the ascending aorta in BAV and tricuspid aortic valve (TAV) patients and their correlation with aortic diameter and patient age. Methods: A total of 376 patients from our institution&apos;s clinical database were included in the retrospective analysis. These patients underwent either elective surgery for ascending aorta dilation or emergency surgery for aortic dissection, either isolated or with a structurally diseased aortic valve. After excision, the ascending aorta samples were analysed by a pathologist. Results: On histological examination, a higher degree of elastic fibre fragmentation and loss and mucoid extracellular matrix accumulation was present in the samples from TAV patients when compared with that from BAV patients (P &lt; 0.001). However, correlation was poor for all variables when considering aortic diameter and histological abnormalities or age and histological abnormalities in both BAV and TAV patients. Conclusions: Our study demonstrates a greater incidence of severe histological abnormalities in TAV patients when compared with BAV patients.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Cardio-Thoracic Surgery

ISSN

1010-7940

e-ISSN

—

Volume of the periodical

59

Issue of the periodical within the volume

5

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

1103-1108

UT code for WoS article

000661342500024

EID of the result in the Scopus database

2-s2.0-85106537779