Acute Management Should Be Optimized in Patients with Less Specific Stroke Symptoms: Findings from a Retrospective Observational Study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10426167" target="_blank" >RIV/00216208:11150/21:10426167 - isvavai.cz</a>

Alternative codes found

RIV/00179906:_____/21:10426167

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sds674IV1p" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=sds674IV1p</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm10051143" target="_blank" >10.3390/jcm10051143</a>

Result language

angličtina

Original language name

Acute Management Should Be Optimized in Patients with Less Specific Stroke Symptoms: Findings from a Retrospective Observational Study

Original language description

Anterior circulation stroke (ACS) is associated with typical symptoms, while posterior circulation stroke (PCS) may cause a wide spectrum of less specific symptoms. We aim to assess the correlation between the initial presentation of acute ischemic stroke (AIS) symptoms and the treatment timeline. Using a retrospective, observational, single-center study, the set consists of 809 AIS patients treated with intravenous thrombolysis (IVT) and/or endovascular treatment (EVT). We investigate the impact of baseline clinical AIS symptoms and the affected vascular territory on recanalization times in patients treated with IVT only and EVT (+/- IVT). Regarding the IVT-only group, increasing the National Institutes of Health Stroke Scale (NIHSS) score on admission and speech difficulties are associated with shorter (by 1.59 +/- 0.76 min per every one-point increase; p = 0.036, and by 24.56 +/- 8.42 min; p = 0.004, respectively) and nausea/vomiting with longer (by 43.72 +/- 13.13 min; p = 0.001) onset-to-needle times, and vertigo with longer (by 8.58 +/- 3.84 min; p = 0.026) door-to-needle times (DNT). Regarding the EVT (+/- IVT) group, coma is associated with longer (by 22.68 +/- 6.05 min; p = 0.0002) DNT, anterior circulation stroke with shorter (by 47.32 +/- 16.89 min; p = 0.005) onset-to-groin time, and drooping of the mouth corner with shorter (by 20.79 +/- 6.02 min; p = 0.0006) door-to-groin time. Our results demonstrate that treatment is initiated later in strokes with less specific symptoms than in strokes with typical symptoms.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Medicine [online]

ISSN

2077-0383

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

5

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

1143

UT code for WoS article

000628244300001

EID of the result in the Scopus database

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