Evidences for a Role of Gut Microbiota in Pathogenesis and Management of Epilepsy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10428130" target="_blank" >RIV/00216208:11150/21:10428130 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/21:00075210 RIV/00023884:_____/21:00009025 RIV/00064203:_____/21:10428130 RIV/00216208:11130/21:10428130

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tZHb.mwbcL" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=tZHb.mwbcL</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms22115576" target="_blank" >10.3390/ijms22115576</a>

Result language

angličtina

Original language name

Evidences for a Role of Gut Microbiota in Pathogenesis and Management of Epilepsy

Original language description

Epilepsy as a chronic neurological disorder is characterized by recurrent, unprovoked epileptic seizures. In about half of the people who suffer from epilepsy, the root cause of the disorder is unknown. In the other cases, different factors can cause the onset of epilepsy. In recent years, the role of gut microbiota has been recognized in many neurological disorders, including epilepsy. These data are based on studies of the gut microbiota-brain axis, a relationship starting by a dysbiosis followed by an alteration of brain functions. Interestingly, epileptic patients may show signs of dysbiosis, therefore the normalization of the gut microbiota may lead to improvement of epilepsy and to greater efficacy of anticonvulsant drugs. In this descriptive review, we analyze the evidences for the role of gut microbiota in epilepsy and hypothesize a mechanism of action of these microorganisms in the pathogenesis and treatment of the disease. Human studies revealed an increased prevalence of Firmicutes in patients with refractory epilepsy. Exposure to various compounds can change microbiota composition, decreasing or exacerbating epileptic seizures. These include antibiotics, epileptic drugs, probiotics and ketogenic diet. Finally, we hypothesize that physical activity may play a role in epilepsy through the modulation of the gut microbiota.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV19-04-00560" target="_blank" >NV19-04-00560: Validation of the ratio of brain derived neurotrophic factor (BDNF) and pro-BDNF as biological marker of Alzheimer´s disease (AD): correlation to plasminogen activator inhibitor-1 (PAI-1)/tissue-type plasminogen activator (tPA) and clinical data</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences [online]

ISSN

1422-0067

e-ISSN

—

Volume of the periodical

22

Issue of the periodical within the volume

11

Country of publishing house

CH - SWITZERLAND

Number of pages

14

Pages from-to

5576

UT code for WoS article

000660227800001

EID of the result in the Scopus database

2-s2.0-85106438169