Presence of circulating tumor cells in a patient with multiple invasive basal cell carcinoma - a case report

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F21%3A10429640" target="_blank" >RIV/00216208:11150/21:10429640 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921805 RIV/00216208:11110/21:10429640 RIV/00179906:_____/21:10429640 RIV/00064173:_____/21:N0000035
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=21AZN3QD4m" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=21AZN3QD4m</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.48095/ccachp202164" target="_blank" >10.48095/ccachp202164</a>

Result language
angličtina
Original language name
Presence of circulating tumor cells in a patient with multiple invasive basal cell carcinoma - a case report
Original language description
Background: Basal cell carcinoma (BCC) is the most frequent skin cancer worldwide, however, its metastatic spreading is extremely rare. Case: We present a case of advanced BCC with rapid growth of new tumor lesions in a patient who was later diagnosed with Gorlin syndrome. Due to the advanced disease stage, the patient was examined for circulating tumor cells (CTCs), which are used as a prognostic marker in some metastatic malignancies. To date, no studies have been found that could assess the BCC tumor and the presence of CTCs in peripheral blood. CTCs were obtained after each surgical excision and during systemic oncological therapy from the peripheral venous blood by size-based isolation method (Metacell(R)) and cultured in vitro for 7 days. CTCs were enriched by size-based separation and examined using vital fluorescence microscopy. Cytomorphological comparison of CTCs with cells from the tumor lesions was provided. In the course of the treatment, the CTCs count in the blood decreased after surgical removal of the tumorous mass, but finally, the sustained and persisting decrease in CTCs was achieved with a hedgehog pathway inhibitor treatment. Conclusion: The detection of CTCs points a systematic disease behavior in this case.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30212 - Surgery

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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