Glycine as a conditionally essential amino acid and its relationship to L-serine

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F25%3A10498982" target="_blank" >RIV/00216208:11150/25:10498982 - isvavai.cz</a>

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8xts9eVQyR" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=8xts9eVQyR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.metabol.2025.156330" target="_blank" >10.1016/j.metabol.2025.156330</a>

Result language

angličtina

Original language name

Glycine as a conditionally essential amino acid and its relationship to L-serine

Original language description

Glycine is a conditionally essential amino acid obtained from food and synthesized in the body, primarily from L-serine. Glycine deficiency has been reported due to inadequate protein intake, malnutrition, late gestation, diabetes, insulin resistance, and increased exposure to xenobiotics. Because of the close links in glycine and L-serine metabolism mediated by serine hydroxymethyltransferase (SHMT), decreased concentrations of both amino acids coincide in most glycine-deficient states. The consequence is a widespread impact on metabolism, including altered synthesis of glutathione, collagen, nucleotides, and one-carbon units, impaired antioxidant defense, cytoprotection, conjugation, and neurotransmission and increased levels of homocysteine and deoxysphingolipids. It can, therefore, be assumed that, rather than glycine alone, its coadministration with L-serine is more appropriate in glycine-deficient conditions. Replacing a part of the glycine with L-serine should avoid (i) glycine flux through SHMT towards L-serine associated with the loss of methylenetetrahydrofolate, a substance essential for methylation reactions, and (ii) ammonia formation due to glycine flux through the glycine cleavage system. Unfortunately, studies comparing the effects of separate administration of glycine and its coadministration with L-serine do not exist. Well-controlled studies in subjects without glycine deficit are required to examine the potential benefits of high doses of glycine as a pharmaconutrient.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Metabolism: Clinical and Experimental

ISSN

0026-0495

e-ISSN

1532-8600

Volume of the periodical

170

Issue of the periodical within the volume

Sept

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

156330

UT code for WoS article

001516239600001

EID of the result in the Scopus database

2-s2.0-105008112102