Carbonylative lactonization via carbonyl oxygen attack: a short and selective total synthesis of uncinine
Result description
A novel cytotoxic butenolide alkaloid, uncinine, has been synthesized in 8 steps from propargyl alcohol. The key step of the sequence was Pd-catalyzed carbonylative lactonization with the participation of an oxo function as the internal nucleophile
Keywords
The result's identifiers
Result code in IS VaVaI
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Carbonylative lactonization via carbonyl oxygen attack: a short and selective total synthesis of uncinine
Original language description
A novel cytotoxic butenolide alkaloid, uncinine, has been synthesized in 8 steps from propargyl alcohol. The key step of the sequence was Pd-catalyzed carbonylative lactonization with the participation of an oxo function as the internal nucleophile
Czech name
Karbonylativní laktonizace prostřednictvím ataku karbonylu: efektivní totální syntéza uncininu
Czech description
Nově izolovaný cytotoxický alkaloid uncinin byl syntetizován v 8 krocích z propargylalkoholu. Klíčovým krokem sekvence byla Pd-katalyzovaná karbonylativní laktonizace s participací oxo skupiny jako interního nukleofilu
Classification
Type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Z - Vyzkumny zamer (s odkazem do CEZ)
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Tetrahedron Letters
ISSN
0040-4039
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
47
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
8137-8140
UT code for WoS article
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EID of the result in the Scopus database
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Basic information
Result type
Jx - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP
CC - Organic chemistry
Year of implementation
2005