The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F05%3A00007082" target="_blank" >RIV/00216208:11160/05:00007082 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes
Original language description
Sibutramine is an anti-obesity drug sold as racemic mixture. Lower biotransformation of R-sibutramine, together with its higher effectiveness in depressing food intake and decreasing body weight make this enantiomer more advantageous
Czech name
Stereoselektivní biotransformace sibutraminu vjaterních mikrosomech potkana a primární kultuře potkaních hepatocytů
Czech description
Stereoselektivní biotransformace sibutraminu vjaterních mikrosomech potkana a primární kultuře potkaních hepatocytů

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
<a href="/en/project/LN00B125" target="_blank" >LN00B125: Research Centre of Structure and Mechanism of Action of Potential Drugs</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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